Caudal dysgenesis in islet‐1 transgenic mice

Sirenomelia Syndrome (caudal Dysgenesis): a Case Report

Sirenomelia is a rare congenital anomaly with an incidence of one in 100,000 pregnancies. It is also called as Mermaid Syndrome because of fused leg, giving appearance of mermaid’s tail. The cause of the condition is probably due to abnormalities in gastrulation in caudal segments. It was initially termed caudal regression, but it is clear that structures do not regress, they simply do not form...

Fkh5-deficient mice show dysgenesis in the caudal midbrain and hypothalamic mammillary body.

The murine winged helix gene Fkh5 is specifically expressed in the developing central nervous system (CNS). Early embryonic Fkh5 expression is restricted to the mammiliary body region of the caudal hypothalamus, midbrain, hindbrain and spinal cord. Postnatally, signals persist in specific nuclei of the mammillary body and in the midbrain. We generated Fkh5 deficient mice by homologous recombina...

Segmental spinal dysgenesis with caudal agenesis in a Holstein calf

A rare complex dysraphic malformation, comprising segmental spinal dysgenesis with caudal agenesis, was found in a Holstein calf that was unable to stand and was slightly short at the lumbosacral spine with taillessness. The thoracolumbar and sacrococcygeal regions of the midline axial segments showed severe deformities. In the spinal cord, the thoracolumbar region showed severe constriction wi...

Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator.

Adrenocortical dysplasia (acd) is a spontaneous autosomal recessive mouse mutant with developmental defects in organs derived from the urogenital ridge. In surviving adult mutants, adrenocortical dysplasia and hypofunction are predominant features. Adults are infertile due to lack of mature germ cells, and 50% develop hydronephrosis due to ureteral hyperplasia. We report the identification of a...

Thymus dysgenesis in nude (nu nu) mice.